Musculoskeletal Research Training Program (T32)

This NIH training program boasts a group of highly qualified mentors in state-of-the-art research environments, providing an ideal modern setting for training young scientists.

2nd Annual Combined T32 Symposium - U of MN/Mayo - October 4, 2017 

2017mayosymall 

Symposium program and more 

The University of Minnesota has a long and rich tradition in training individuals to study musculoskeletal biology and disease. The research strengths of the training program are in the areas of animal models for bone cancer research and osteoarthritis, outcomes-based research for orthopaedic and bone cancer treatments, adult stem cell research, molecular biology and genomics research.

Our goals:

  • Train predoctoral students and postdoctoral fellows for research careers as basic scientists or clinical investigators studying the causes and treatments of musculoskeletal diseases
  • Develop an educational environment for students and postdoctoral fellows, which encompasses a modern spectrum of research in musculoskeletal diseases, including basic discovery, investigation of musculoskeletal disease models and study of outcomes of standard treatments. 

Programs

The strengths of musculoskeletal research at the University of Minnesota are in the areas of basic discovery, mechanisms of musculoskeletal disease in animal models and outcomes-based research of standard clinical treatments. These strengths are found in the four primary focus groups. 

These focus groups allow for and encourage cross-disciplinary interactions between molecular biologists, (stem) cell biologists, orthopaedic surgeons, veterinary researchers and bioengineers. The primary interests of each faculty member guided his/her placement into the groups; however, many faculty members make significant contributions to more than one focus group.

Musculoskeletal Cancer Biology and Therapeutics

(D.R. Clohisy,* M. Garwood, D. Largaespada, J. Modiano)

The collective focus of this group is to understand the etiology, progression and clinical sequelae of musculoskeletal cancers and to develop new therapies for treatment and prevention; specific areas of research include the cellular mechanisms regulating osteolysis in cancer; bone cancer-associated pain and tumor metastasis to bone; animal models of sarcoma; clinical epidemiology research in osteosarcoma and rhabdomyosarcoma; and the development of new techniques in MR imaging and oncology.

Osteoarthritis and Cartilage Biology Group

(C. Carlson,* J. Bechtold, P. Ludewig, G.E. Pluhar)

This group has a common interest in understanding the etiology and treatments of osteoarthritis. Specific areas of research include the development and validation of animal models of osteoarthritis; bone fracture repair; biomechanics of the shoulder joint; and the pathophysiology of degenerative osteoarthritis of the spine.

Musculoskeletal Development Group

(R. Gopalakrishnan, D. Kaufman, K. Mansky, L. Potter, M. O'Connor)

This group is unified by the common interest of understanding the molecular mechanisms that regulate skeletal development, maturation, and differentiation. Specific areas of research include osteoblast and osteoclast biology and the role of these cells in the physiologic and pathophysiologic formation of the skeleton; mechanisms involved in limb regeneration in xenopus tadpoles; skeletal aberrations occurring in dwarfism; and estrogen signal transduction cascades in bone metabolism and cancer biology.

Epidemiology and Clinical Outcomes Research Group

(L. Spector*, M. Swiontkowski)

This group of investigators applies state-of-the-art epidemiologic and clinical outcomes research methodologies to critically evaluate a wide variety of musculoskeletal treatments. This group has multiple strengths but the two most important are their access to large patient/sample populations through cooperative multi-institutional trials and their international reputation in orthopaedic-based clinical outcomes research. Specific areas of research include the assessment of functional outcomes for the treatment of musculoskeletal conditions and the etiology and behavior of musculoskeletal cancers.

Leadership & faculty

Interested in becoming a faculty mentor? Please complete this mentor application form.

Director

Denis Clohisy, MD
Degree: Northwestern University Medical School, 1983 (MD)
Interests: Pathogenesis of bone cancer pain
Email: clohi001@umn.edu
Publications on PubMed

Co-Directors

Cathy Carlson, DVM, PhD
Degree: University of Minnesota, 1983 (DVM), North Carolina State University 1986 (PhD)
Interests: Pathogenesis of orthopaedic diseases
Email: carls099@umn.edu
Publications on PubMed 

Kim C. Mansky, PhD
Degree: University of Wisconsin-Madison, 1997 (PhD)
Interests: Bone biology with an emphasis on osteoclast differentiation
Email: kmansky@umn.edu
Publications on PubMed

Advisory Council

Paula Ludewig, PhD
Degree: University of Iowa, 1998 (PhD)
Interests: Biomechanical pathogenesis of orthopaedic diseases, with focus on shoulder joint soft tissue diseases
Email: ludew001@umn.edu
Publications on PubMed

Lincoln Potter, PhD
Degree: Vanderbilt University, 1994 (PhD)
Interests: Signal trasduction, natriuretic peptides, guanylyl cyclase receptors and cGMP
Publications on PubMed

Logan Spector, PhD
Degree: Emory University, 2002(PhD)
Interests: Etiology of childhood cancer, with a focus on leukemia, hepatoblastoma, and osteosarcoma 
E-Mail: spector@umn.edu
Publications on PubMed

Faculty

Victor Barocas, PhD
Degree: University of Minnesota, 1996(PhD)
Interests: Biomechanics of musculoskeletal tissues
Email: baroc001@umn.edu
Publications on PubMed

Joan Bechtold, PhD
Degree: University of Minnesota, 1987(PhD)
Interests: Bone healing and implant fixation in conditions of comorbidity
Email: bechtold@umn.edu
Publications on PubMed 

Bryce Binstadt, MD, PhD
Degree: Mayo Medical School, 1999 (MD, PhD)
Interests: Animal models of autoimmune inflammatory disease
Email: binstadt@umn.edu
Publications on PubMed 

Michael Garwood, PhD
Degree: University of California, Santa Cruz, 1985(PhD)
Interests: Developing advanced MRI and MRS techniques
Email: gar@umn.edu
Publications on PubMed

Raj Gopalakrishnan, DDS, PhD
Degree: Ohio State University, 1999(PhD)
Interests: Role of BMP signaling in Bone Remodeling
Email: gopal007@umn.edu
Publications on PubMed

Eric Jensen, PhD
Degree: University of Colorado, 2003(PhD)
Interests: Molecular regulators of osteoblast and osteoclast biology
Email: jens0709@umn.edu
Publications on PubMed 

Dan Kaufman, PhD
Degree: Mayo Medical School, 1996 (MD, PhD)
Interests: Developing new cancer therapies
Email: kaufm020@umn.edu
Publications on PubMed

Yasuhiko Kawakami, PhD
Degree: Okayama University, Japan, 1996 (PhD)
Interests: Mechanisms of limb development and regeneration
Email: kawak005@umn.edu
Publications on PubMed 

David Largaespada, PhD
Degree: Ph.D., Genetics, Cell Biology and Development
Interests: Cancer Genetics, Insertional Mutagenesis, Mouse Transgenesis, Link to Genetics, Cell Biology and Development
Email: larga002@umn.edu
Publications on PubMed

Alice Larson, PhD
Degree: University of Minnesota, 1977(PhD)
Interests: Chronic pain and allodynia associated with fibromyalgia syndrome; regulation of nociception by thalamic mast cells; brown adipose tissue
Email: larso011@umn.edu 
Publications on PubMed

Dawn Lowe, PhD
Degree: Unviersity of Georgia, 1994(PhD)
Interests: Mechanisms of musculoskeletal deterioration and reversal with age and disease
Email: lowex017@umn.edu
Publications on PubMed

Jaime Modiano, VMD, PhD
Degree: University of Pennsylvania, 1991(DVM, PhD)
Interests: Cell growth regulation in cancer – osteosarcoma
Email: modiano@umn.edu
Publications on PubMed

Branden S. Moriarity, PhD
Degree: University of Minnesota, 2012 (PhD)
Interests: Pediatric cancer genetics, immunotherapy, and gene therapy 
Email: mori0164@umn.edu
Publications on PubMed 

G. Elizabeth Pluhar, PhD
Degree: Oregon State University, 1989 (DVM), University of Wisconsin, 1999 (PhD)
Interests: Animal models in orthopaedic diseases
Email: pluha006@umn.edu
Publications on PubMed

Lincoln Potter, PhD
Degree: Vanderbilt University, 1994 (PhD)
Interests: Structure, function and regulation of natriuretic peptides and their guanylyl cyclase-linked receptors
Email: potter@umn.edu
Publications on PubMed

Subree Subramanian, PhD
Degree: Jawaharlal Nehru University, India, 2004 (PhD)
Interests: Mechanisms of osteo-sarcoma development and progression
Email: subree@umn.edu
Publications on PubMed

Troy Trumble, DVM, PhD
Degree: Michigan State Universitym 1995 (DVM), Colorado State University (PhD)
Interests: Translational studies of the onset and progression of osteoarthritis 
Email: trumb016@umn.edu 
Publications on PubMed

Trainees

Predoctoral

Brandon Diessner
Brandon Diessner

Current Department: Department of Pediatrics
Graduate Program: Epidemiology
Appointment date:  May 1, 2018
Mentor(s): Logan G. Spector, PhD
Project Description: My research focuses on sarcoma etiology and outcomes in pediatric and young adult populations. I am particularly interested in identifying genetic variants that predispose individuals to osteosarcoma and Ewing sarcoma development, as well as identifying risk factors for metastatic disease at diagnosis. 

Bora Faulkner
faulkner

Department: Genetics, Cell Biology and Developmental (GCD) 
Graduate Program: Molecular, Cellular, Developmental Biology and Genetics (MCDB&G) 
Appointment Date: May 1, 2018
Mentor(s): Kim Mansky, PhD
Project Description: Bone undergoes remodeling by balancing the activities of bone-forming  osteoblasts and bone lystic osteoclasts. Disruption of this balance results in bone density-related diseases in humans.  Therefore, it is critical to understand  underlying molecular mechanisms that drives bone homeostasis.  My research project focuses on understanding the mechanism by which histone deacetylase 4 ( HDAC4 ) regulates osteoclasts gene expression and differentiation. 

Craig Kage
Kage

Department: Rehabilitation Medicine
Graduate Program: Rehabilitation Science
Appointment Date: July 1, 2018
Mentor(s): Arin Ellingson, PhD
Project Description: My overall research is centered around cervical spine kinematics.  This includes gross spinal motion analysis using optical motion capture and the validation and utilization of a custom biplane fluoroscopy system for dynamic, three-dimensional spine imaging at the segmental level.  Both of these techniques allow for a detailed understanding of cervical spine motion and valuable comparisons between those with and without neck pain/pathology. The ultimate goal of this research is to better inform clinical practice from both a diagnostic and treatment perspective.

Postdoctoral 

John Looft, PhD
Looft

Department: Physical Medicine & Rehabilitation 
Appointment Date: July 1, 2016
Mentor: Paula Ludewig, PhD
Project Description: Developing a high fidelity shoulder finite element model for clinical applications. The goal of this model is to combine finite element models along with MRI and fluoroscopy to develop predictive models for diagnosing shoulder pain and dysfunction. Additionally working on collaborative research projects improving MRI auto-segmentation software for clinical applications. 

Gengyun (Coco) Le, PhD
Gengyun (Coco) Le

Department: Physical Medicine & Rehabilitation 
Appointment Date: January 1, 2017
Mentor: Dawn Loe, PhD
Project Description: Advancing the musculoskeletal field by investigating how estrogen affects the inflammatory responses and strength recovery following traumatic muscle injury, and how we can utilize our research to develop therapeutic strategies to prevent, lessen, regain, and finally improve muscle strength in females with low levels of circulating ovarian hormones. I’m also interested in the therapy strategies with bone marrow transplantation and recombinant enzyme modifying behavioral and musculoskeletal impairment in Hurler mice, a mouse model for Hurler Syndrome (or MPS I-H).

Alumni

Predoctoral

Laura Antos, PhD
Project: Characterizing ATP's effect on natriuretic peptide receptors in relation to long bone growth using fibroblast cell cultures.
Mentor: Lincoln Potter, PhD

Emily Bermel
Bermel

Project: My research deals with the lumbar facet capsular ligament (FCL). The FCL guides and constrains spinal motions such as flexion/extension, lateral bending, and axial rotation. It is comprised of highly aligned collagen fiber bundles on the posterior surface and nonaligned elastin fibers on the anterior surface. My goal is to develop a theoretical/computational model of the degeneration process using growth and remodeling theories in conjunction with realistic models of the tissue geometry and properties. 
Mentor: Victor Barocas, PhD

Charles Billington, PhD
Project: Examine the spectrum of craniofacial malformations resulting from mutation of the gene Twisted Gastrulation.
Mentor: Anna Petryk, MD

Nicholas Blixt
Blixt

Project: I am researching the molecular mechanisms behind how histone deacetylase enzymes regulate osteoclast differentiation. The end goal of this research is to provide mechanistic insight into controlling osteoclast differentiation as potential new therapy for osteoporosis or other diseases characterized by uncontrolled bone loss. This compliments my main research interests, which involve elucidating the transcriptional and epigenetic profiles among cell types that produce and maintain the skeletal system, as well as how the skeleton is modeled and remodeled based on the activity of these cells. 
Mentor: Kim Mansky, PhD

Christina Brakken-Thal, PhD
Project: To understand how Decapentapolegic (Dpp), a BMP protein, is regulated to pattern the dorsal surface of the embryo.
Mentor: Michael O'Connor, PhD

Aaron Broege, PhD
Project: To determine how delta EF1 regulates osteoblast development.
Mentor: Michael Sanders, PhD

Amy Claeson, PhD
Amy Claeson Photo

Project: Develop a multi-scale understanding of the structure and mechanical properties of the lumbar facet capsular ligament (FCL) at the spinal, segmental and tissue levels
Mentor: Victor Barocas, PhD

Aaron Edmund, PhD
Aaron Edmund Photo

Project: My research is focused on mechanisms of activation and inactivation of natriuretic peptide receptors
Mentor: Lincoln Potter, PhD

Arin Ellingson, PhD
Project: To measure the helical axis of motion of lumbar spinal motion segments using a human cadaveric model to establish factors that are distinguishable and correlated by the location and/or direction of the helical axis throughout motion
Mentor: David Nuckley, PhD

Sarah Frommer, PhD
Project: We are investigating the use of stem cells as treatment for Duchenne Muscular Dystrophy.
Mentor: Catherine Verfaillie, MD

Rachel Kahler, PhD
Project: To define the intentions of the transcription factors, Runx2 and LEF1, and determining the role of LEF1 in osteoblast differentiation.
Mentor: Jennifer Westendorf, PhD

Rebekah Lawrence, PT, DPT, OCS
Lawrence

Project: My primary research aim is to develop a biomechanical model based in kinematic data that will help establish a foundation for a clinical examination of movement impairments for people with shoulder pain. I also plan to attempt to identify the relationships between these biomechanical factors and potential underlying pathoanatomy that may be contributing to the painful condition. We believe this model will result in a more specific diagnostic paradigm from which doctors and physical therapists base their interventions.
Mentor: Paula Ludewig, PhD, PT

Margaret McNulty, PhD
Project Description: To develop a histological grading scheme for osteoarthritis in mice.
Mentor: Cathy Carlson, DVM, PhD

Branden Moriarity, PhD
Project: Candidate genes from a forward genetic screen to identify osteosarcoma (OS) development and metastasis genes.
Mentor: David Largaespada, PhD

Christopher Peters, PhD
Project: Unique cellular interactions that occur within the bone microenvironment in both osteolytic and osteoblastic models of bone cancer.
Mentor: Patrick Mantyh, PhD, JD

Jerid Robinson, PhD
Project: The natriuretic peptide receptor B (NPR-B), which has relevance in musculoskeletal research via its effects on long bone growth.
Mentor: Lincoln Potter, PhD

Brandon Smeester
Smeester

Department: Pediatrics
Graduate Program: Comparative & Molecular Biosciences 
Appointment Date: May 1, 2016
Mentor(s): Branden Moriarty, PhD/David Largaespada, PhD
Project Description: My research is focused on the validation of candidate cancer genes using the CRISPR system and testing novel therapuetic targets to treat osteosarcoma. 

Postdoctoral Alumni

Randy Daughters, PhD
Project: Understanding the origin and specification of satellite cells during embryonic development and their contribution to muscle regeneration in Xenopus Laevis tadpole tails.
Mentor: Jonathan Slack, PhD

Dawne Dougherty, PhD
Project: To understand prostate cancer as it progresses to bone metastases, particularly with respect to the contributing hormonal signaling pathways.
Mentor: Michel Sanders, PhD

Emily Gillespie, MD
Project: Underlying systemic autoimmune disease with the hope of improving disease management and generating better therapies.
Mentor: Timothy Behrens, MD

Curtis Goreham-Voss, PhD
Project: Applying finite element analysis to simulate the implant-bone fixation.
Mentor: Joan Bechtold, PhD

Eric Jensen, PhD
Project: Studying interactions between Runx2 and histone deacetylases in the regulation of bone-specific genes.
Mentor: Jennifer Westendorf, PhD

Kristina Kiefer, DVM
Project: Evaluating the use of canine adipose derived stem cells as a therapeutic modality for the treatment of intervertebral disc disease and degenerative myelopathy, as well as other various orthopedic conditions in canines.
Mentor: Elizabeth Pluhar, DVM, PhD

Amanda Leightner, PhD
Leightner

Project: To better understand the role of PKD2 in osteoclast differentiation and function. We hypothesize that PKD2 may direct osteoclastogenesis through both control of pre-osteoclast fusion and regulation of the actin cytoskeletal network and podosome dynamics. 
Mentor: Eric Jensen, PhD

Carol Lin, MD
Project: Compare reoperation rates and outcomes in patients not enrolled or excluded from SPRINT to assess the influence of enrollment in the trial.
Mentor: Marc Swiontkowski, MD

Applications & recruitment

For info on how to apply, elibility, and criteria, see our FAQ page.

Email Tanya Doble, research administrative specialist, to inquire about the status of open positions.

Relevant documents