Musculoskeletal Research Training Program (T32)

submenu

This NIH training program boasts a group of highly qualified mentors in state-of-the-art research environments, providing an ideal modern setting for training young scientists.

1st Annual Combined T32 Symposium – U of MN/Mayo – April 21, 2016

First Annual Combined Symposia of Mayo and UMN 2016

The University of Minnesota has a long and rich tradition in training individuals to study musculoskeletal biology and disease. The research strengths of the training program are in the areas of animal models for bone cancer research and osteoarthritis, outcomes-based research for orthopaedic and bone cancer treatments, adult stem cell research, molecular biology and genomics research.

Our goals:

  • Train predoctoral students and postdoctoral fellows for research careers as basic scientists or clinical investigators studying the causes and treatments of musculoskeletal diseases
  • Develop an educational environment for students and postdoctoral fellows, which encompasses a modern spectrum of research in musculoskeletal diseases, including basic discovery, investigation of musculoskeletal disease models and study of outcomes of standard treatments. 

Programs

The strengths of musculoskeletal research at the University of Minnesota are in the areas of basic discovery, mechanisms of musculoskeletal disease in animal models and outcomes-based research of standard clinical treatments. These strengths are found in the four primary focus groups. 

These focus groups allow for and encourage cross-disciplinary interactions between molecular biologists, (stem) cell biologists, orthopaedic surgeons, veterinary researchers and bioengineers. The primary interests of each faculty member guided his/her placement into the groups; however, many faculty members make significant contributions to more than one focus group.

Musculoskeletal Cancer Biology and Therapeutics


(D.R. Clohisy,* M. Garwood, D. Largaespada, J. Modiano)


The collective focus of this group is to understand the etiology, progression and clinical sequelae of musculoskeletal cancers and to develop new therapies for treatment and prevention; specific areas of research include the cellular mechanisms regulating osteolysis in cancer; bone cancer-associated pain and tumor metastasis to bone; animal models of sarcoma; clinical epidemiology research in osteosarcoma and rhabdomyosarcoma; and the development of new techniques in MR imaging and oncology.



Osteoarthritis and Cartilage Biology Group


(C. Carlson,* J. Bechtold, P. Ludewig, G.E. Pluhar)


This group has a common interest in understanding the etiology and treatments of osteoarthritis. Specific areas of research include the development and validation of animal models of osteoarthritis; bone fracture repair; biomechanics of the shoulder joint; and the pathophysiology of degenerative osteoarthritis of the spine.
 


Musculoskeletal Development Group


(R. Gopalakrishnan, D. Kaufman, K. Mansky, L. Potter, M. O'Connor)


This group is unified by the common interest of understanding the molecular mechanisms that regulate skeletal development, maturation, and differentiation. Specific areas of research include osteoblast and osteoclast biology and the role of these cells in the physiologic and pathophysiologic formation of the skeleton; mechanisms involved in limb regeneration in xenopus tadpoles; skeletal aberrations occurring in dwarfism; and estrogen signal transduction cascades in bone metabolism and cancer biology.
 


Epidemiology and Clinical Outcomes Research Group


(L. Spector*, M. Swiontkowski)


This group of investigators applies state-of-the-art epidemiologic and clinical outcomes research methodologies to critically evaluate a wide variety of musculoskeletal treatments. This group has multiple strengths but the two most important are their access to large patient/sample populations through cooperative multi-institutional trials and their international reputation in orthopaedic-based clinical outcomes research. Specific areas of research include the assessment of functional outcomes for the treatment of musculoskeletal conditions and the etiology and behavior of musculoskeletal cancers.



Leadership & faculty

Interested in becoming a faculty mentor? Please complete this mentor application form.

Director 


Denis Clohisy, MD

Degree: Northwestern University Medical School, 1983 (MD)

Interests: Pathogenesis of bone cancer pain

Email: clohi001@umn.edu

Publications on PubMed

Co-Directors


Cathy Carlson, DVM, PhD

Degree: University of Minnesota, 1983 (DVM), North Carolina State University 1986 (PhD)

Interests: Pathogenesis of orthopaedic diseases

Email: carls099@umn.edu
Publications on PubMed 



Kim C. Mansky, PhD

Degree: University of Wisconsin-Madison, 1997 (PhD)

Interests: Bone biology with an emphasis on osteoclast differentiation

Email: kmansky@umn.edu
Publications on PubMed


Advisory Council


Paula Ludewig, PhD
Degree: University of Iowa, 1998 (PhD)

Interests: Biomechanical pathogenesis of orthopaedic diseases, with focus on shoulder joint soft tissue diseases
Email: ludew001@umn.edu
Publications on PubMed



Lincoln Potter, PhD

Degree: Vanderbilt University, 1994 (PhD)

Interests: Signal trasduction, natriuretic peptides, guanylyl cyclase receptors and cGMP
Publications on PubMed



Logan Spector, PhD

Degree: Emory University, 2002(PhD)

Interests: Etiology of childhood cancer, with a focus on leukemia, hepatoblastoma, and osteosarcoma 

E-Mail: spector@umn.edu
Publications on PubMed


Faculty

Victor Barocas, PhD

Degree: University of Minnesota, 1996(PhD)

Interests: Biomechanics of musculoskeletal tissues

Email: baroc001@umn.edu
Publications on PubMed



Joan Bechtold, PhD

Degree: University of Minnesota, 1987(PhD)

Interests: Bone healing and implant fixation in conditions of comorbidity

Email: bechtold@umn.edu
Publications on PubMed 



Bryce Binstadt, MD, PhD

Degree: Mayo Medical School, 1999 (MD, PhD)

Interests: Animal models of autoimmune inflammatory disease

Email: binstadt@umn.edu
Publications on PubMed 



Michael Garwood, PhD

Degree: University of California, Santa Cruz, 1985(PhD)

Interests: Developing advanced MRI and MRS techniques
Email: gar@umn.edu
Publications on PubMed



Raj Gopalakrishnan, DDS, PhD

Degree: Ohio State University, 1999(PhD)

Interests: Role of BMP signaling in Bone Remodeling

Email: gopal007@umn.edu
Publications on PubMed



Eric Jensen, PhD

Degree: University of Colorado, 2003(PhD)

Interests: Molecular regulators of osteoblast and osteoclast biology

Email: jens0709@umn.edu
Publications on PubMed 


Dan Kaufman, PhD

Degree: Mayo Medical School, 1996 (MD, PhD)

Interests: Developing new cancer therapies
Email: kaufm020@umn.edu
Publications on PubMed
 


Yasuhiko Kawakami, PhD

Degree: Okayama University, Japan, 1996 (PhD)

Interests: Mechanisms of limb development and regeneration

Email: kawak005@umn.edu
Publications on PubMed 
 


David Largaespada, PhD

Degree: Ph.D., Genetics, Cell Biology and Development

Interests: Cancer Genetics, Insertional Mutagenesis, Mouse Transgenesis, Link to Genetics, Cell Biology and Development

Email: larga002@umn.edu
Publications on PubMed



Alice Larson, PhD

Degree: University of Minnesota, 1977(PhD)

Interests: Chronic pain and allodynia associated with fibromyalgia syndrome; regulation of nociception by thalamic mast cells; brown adipose tissue

Email: larso011@umn.edu 

Publications on PubMed


Dawn Lowe, PhD

Degree: Unviersity of Georgia, 1994(PhD)

Interests: Mechanisms of musculoskeletal deterioration and reversal with age and disease

Email: lowex017@umn.edu
Publications on PubMed



Jaime Modiano, VMD, PhD

Degree: University of Pennsylvania, 1991(DVM, PhD)

Interests: Cell growth regulation in cancer – osteosarcoma
Email: modiano@umn.edu
Publications on PubMed



Branden S. Moriarity, PhD

Degree: University of Minnesota, 2012 (PhD)

Interests: Pediatric cancer genetics, immunotherapy, and gene therapy 
Email: mori0164@umn.edu
Publications on PubMed
 


G. Elizabeth Pluhar, PhD

Degree: Oregon State University, 1989 (DVM), University of Wisconsin, 1999 (PhD)

Interests: Animal models in orthopaedic diseases 

Email: pluha006@umn.edu
Publications on PubMed



Lincoln Potter, PhD

Degree: Vanderbilt University, 1994 (PhD)

Interests: Structure, function and regulation of natriuretic peptides and their guanylyl cyclase-linked receptors

Email: potter@umn.edu
Publications on PubMed


Subree Subramanian, PhD

Degree: Jawaharlal Nehru University, India, 2004 (PhD)

Interests: Mechanisms of osteo-sarcoma development and progression

Email: subree@umn.edu
Publications on PubMed



Troy Trumble, DVM, PhD

Degree: Michigan State Universitym 1995 (DVM), Colorado State University (PhD)

Interests: Translational studies of the onset and progression of osteoarthritis 

Email: trumb016@umn.edu 

Publications on PubMed

Trainees

Predoctoral

Emily Bermel
Bermel
Department: Biomedical Engineering 
Graduate Program: Biomedical Engineering
Appointment Date: July 1, 2016
Mentor: Victor Barocas, PhD
Project Description: My research deals with the lumbar facet capsular ligament (FCL). The FCL guides and constrains spinal motions such as flexion/extension, lateral bending, and axial rotation. It is comprised of highly aligned collagen fiber bundles on the posterior surface and nonaligned elastin fibers on the anterior surface. My goal is to develop a theoretical/computational model of the degeneration process using growth and remodeling theories in conjunction with realistic models of the tissue geometry and properties. 

Nicholas Blixt
Blixt
Department: Developmental & Surgical Sciences 
Graduate Program: Molecular, Cellular, Developmental Biology & Genetics
Appointment Date: May 1, 2016
Mentor: Kim Mansky, PhD
Project Description: I am researching the molecular mechanisms behind how histone deacetylase enzymes regulate osteoclast differentiation. The end goal of this research is to provide mechanistic insight into controlling osteoclast differentiation as potential new therapy for osteoporosis or other diseases characterized by uncontrolled bone loss. This compliments my main research interests, which involve elucidating the transcriptional and epigenetic profiles among cell types that produce and maintain the skeletal system, as well as how the skeleton is modeled and remodeled based on the activity of these cells. 

Branden Smeester 
Smeester
Department: Pediatrics
Graduate Program: Comparative & Molecular Biosciences 
Appointment Date: May 1, 2016
Mentor(s): Branden Moriarty, PhD/David Largaespada, PhD
Project Description: My research is focused on the validation of candidate cancer genes using the CRISPR system and testing novel therapuetic targets to treat osteosarcoma. 

Postdoctoral 

John Looft, PhD
Looft
Department: Physical Medicine & Rehabilitation 
Appointment Date: July 1, 2016
Mentor: Paula Ludewig, PhD
Project Description: Developing a high fidelity shoulder finite element model for clinical applications. The goal of this model is to combine finite element models along with MRI and fluoroscopy to develop predictive models for diagnosing shoulder pain and dysfunction. Additionally working on collaborative research projects improving MRI auto-segmentation software for clinical applications. 

Gengyun (Coco) Le, PhD
Gengyun (Coco) Le
Department: Physical Medicine & Rehabilitation 
Appointment Date: January 1, 2017
Mentor: Dawn Loe, PhD
Project Description: Advancing the musculoskeletal field by investigating how estrogen affects the inflammatory responses and strength recovery following traumatic muscle injury, and how we can utilize our research to develop therapeutic strategies to prevent, lessen, regain, and finally improve muscle strength in females with low levels of circulating ovarian hormones. I’m also interested in the therapy strategies with bone marrow transplantation and recombinant enzyme modifying behavioral and musculoskeletal impairment in Hurler mice, a mouse model for Hurler Syndrome (or MPS I-H).

 

Alumni

Predoctoral

Laura Antos, PhD
Project: Characterizing ATP's effect on natriuretic peptide receptors in relation to long bone growth using fibroblast cell cultures.
Mentor: Lincoln Potter, PhD

Charles Billington, PhD
Project: Examine the spectrum of craniofacial malformations resulting from mutation of the gene Twisted Gastrulation.
Mentor: Anna Petryk, MD

Christina Brakken-Thal, PhD
Project: To understand how Decapentapolegic (Dpp), a BMP protein, is regulated to pattern the dorsal surface of the embryo.
Mentor: Michael O'Connor, PhD

Aaron Broege, PhD
Project: To determine how delta EF1 regulates osteoblast development.
Mentor: Michael Sanders, PhD

Amy Claeson, PhD
Amy Claeson Photo

Project:Develop a multi-scale understanding of the structure and mechanical properties of the lumbar facet capsular ligament (FCL) at the spinal, segmental and tissue levels
Mentor: Victor Barocas, PhD

Aaron Edmund, PhD
Aaron Edmund Photo

Project:My research is focused on mechanisms of activation and inactivation of natriuretic peptide receptors
Mentor: Lincoln Potter, PhD

Arin Ellingson, PhD
Project: To measure the helical axis of motion of lumbar spinal motion segments using a human cadaveric model to establish factors that are distinguishable and correlated by the location and/or direction of the helical axis throughout motion
Mentor: David Nuckley, PhD

Sarah Frommer, PhD
Project: We are investigating the use of stem cells as treatment for Duchenne Muscular Dystrophy.
Mentor: Catherine Verfaillie, MD

Rachel Kahler, PhD
Project: To define the intentions of the transcription factors, Runx2 and LEF1, and determining the role of LEF1 in osteoblast differentiation.
Mentor: Jennifer Westendorf, PhD

Rebekah Lawrence, PT, DPT, OCS
Lawrence

Project Description: My primary research aim is to develop a biomechanical model based in kinematic data that will help establish a foundation for a clinical examination of movement impairments for people with shoulder pain. I also plan to attempt to identify the relationships between these biomechanical factors and potential underlying pathoanatomy that may be contributing to the painful condition. We believe this model will result in a more specific diagnostic paradigm from which doctors and physical therapists base their interventions.
Mentor: Paula Ludewig, PhD, PT

Margaret McNulty, PhD
Project Description: To develop a histological grading scheme for osteoarthritis in mice.
Mentor: Cathy Carlson, DVM, PhD

Branden Moriarity, PhD
Project: Candidate genes from a forward genetic screen to identify osteosarcoma (OS) development and metastasis genes.
Mentor: David Largaespada, PhD

Christopher Peters, PhD
Project: Unique cellular interactions that occur within the bone microenvironment in both osteolytic and osteoblastic models of bone cancer.
Mentor: Patrick Mantyh, PhD, JD

Jerid Robinson, PhD
Project: The natriuretic peptide receptor B (NPR-B), which has relevance in musculoskeletal research via its effects on long bone growth.
Mentor: Lincoln Potter, PhD

Postdoctoral Alumni

Randy Daughters, PhD
Project: Understanding the origin and specification of satellite cells during embryonic development and their contribution to muscle regeneration in Xenopus Laevis tadpole tails.
Mentor: Jonathan Slack, PhD

Dawne Dougherty, PhD
Project: To understand prostate cancer as it progresses to bone metastases, particularly with respect to the contributing hormonal signaling pathways.
Mentor: Michel Sanders, PhD

Emily Gillespie, MD
Project: Underlying systemic autoimmune disease with the hope of improving disease management and generating better therapies.
Mentor: Timothy Behrens, MD

Curtis Goreham-Voss, PhD
Project: Applying finite element analysis to simulate the implant-bone fixation.
Mentor: Joan Bechtold, PhD

Eric Jensen, PhD
Project: Studying interactions between Runx2 and histone deacetylases in the regulation of bone-specific genes.
Mentor: Jennifer Westendorf, PhD

Kristina Kiefer, DVM
Project: Evaluating the use of canine adipose derived stem cells as a therapeutic modality for the treatment of intervertebral disc disease and degenerative myelopathy, as well as other various orthopedic conditions in canines.
Mentor: Elizabeth Pluhar, DVM, PhD

Amanda Leightner, PhD
Leightner

Project: To better understand the role of PKD2 in osteoclast differentiation and function. We hypothesize that PKD2 may direct osteoclastogenesis through both control of pre-osteoclast fusion and regulation of the actin cytoskeletal network and podosome dynamics. 
Mentor: Eric Jensen, PhD

Carol Lin, MD
Project: Compare reoperation rates and outcomes in patients not enrolled or excluded from SPRINT to assess the influence of enrollment in the trial.
Mentor: Marc Swiontkowski, MD

Applications & recruitment

For info on how to apply, elibility, and criteria, see our FAQ page.

Email Tanya Doble, research administrative specialist, to inquire about the status of open positions.

Relevant documents